Midlife is a period of profound change for women, and it’s also a time when mental health challenges can increase. Research shows that women aged 45–64 have some of the highest suicide rates among females. This period often coincides with menopause, a time of major hormonal changes that can affect mood, energy, and overall well-being.
Understanding the connection between hormones, mood, and suicide risk is essential for women, their families, and healthcare providers.
Hormonal Changes and Mental Health
During perimenopause and menopause, levels of estrogen and progesterone shift dramatically. These hormones not only affect reproductive health—they also influence brain chemicals like serotonin and dopamine, which help regulate mood, motivation, and calm.
When estrogen and progesterone drop, women may experience:
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Anxiety and irritability
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Persistent sadness or low mood
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Brain fog or memory difficulties
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Sleep disturbances and fatigue
These changes can increase vulnerability to depression and, in severe cases, thoughts of suicide or self-harm.
What the Research Shows
Several recent studies highlight the connection between menopause, hormonal changes, and increased risk of suicide:
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Age at Menopause and Suicide Risk
A 2024 study of over 1.3 million postmenopausal women found that women who went through menopause at younger ages—especially before 40—had a significantly higher risk of suicide. (Frontiers in Psychiatry, DOI: 10.3389/fpsyt.2024.1442991) -
Menopause and Suicide: A Review
A 2025 review of 19 studies reported that most women experience an increased risk of suicidal thoughts or feelings during menopause, especially during perimenopause. Hormonal changes, existing mental health conditions, physical symptoms, and limited social support were key factors. (ResearchGate, DOI: 10.13140/RG.2.2.39635.97155) -
Midlife Women at Risk
Another 2025 study emphasized that women in midlife, particularly during perimenopause, are at an elevated risk for suicidal thoughts due to hormonal fluctuations affecting mental health. (SAGE Journals, DOI: 10.1177/17455057251338941)
Risk Factors to Watch For
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Hormonal Changes: Drops in estrogen and progesterone can affect mood.
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Existing Mental Health Conditions: Depression or anxiety may worsen.
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Physical Symptoms: Hot flashes, sleep problems, and fatigue can add stress.
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Social Isolation: Feeling alone or lacking support can increase risk.
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Life Stressors: Work, caregiving, or relationship challenges.
How Women Can Protect Their Mental Health
Even if insurance doesn’t cover it, investing in your health is essential. Strategies include:
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Hormone Support: Discuss options with a healthcare provider, including hormone therapy if appropriate.
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Functional Medicine: Labs and lifestyle strategies to address underlying imbalances.
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Mental Health Care: Therapy or counseling for emotional support.
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Healthy Habits: Regular exercise, balanced nutrition, stress management, and good sleep routines.
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Social Support: Maintain strong friendships and support networks.
When to Seek Help
If you experience persistent sadness, anxiety, sleep problems, or thoughts of self-harm, seek professional help immediately.
In the U.S., you can contact the National Suicide Prevention Lifeline at 988, available 24/7 for free, confidential support.
Conclusion
Menopause is a natural phase of life, but it comes with real mental health challenges. Hormonal changes, combined with life stressors, can increase the risk of depression and suicidal thoughts in women aged 45–64.
Awareness, early intervention, and supportive care—through conventional or functional medicine—can make a profound difference. Women deserve to feel seen, supported, and empowered to take charge of their mental and emotional health during midlife.
Take Action Today:
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Track your mood, sleep, and energy.
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Discuss hormonal and mental health concerns with your healthcare provider.
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Consider functional medicine strategies to address root causes of imbalance.
Your health, your mood, and your life are worth the investment.
Want to Learn More?
If you’re a woman navigating midlife and want personalized guidance to support your hormones, mood, and overall well-being, I’m here to help.
Schedule a functional medicine discovery call or reach out to me directly to discuss how we can create a plan tailored to your unique needs.
Email: rosie@jrmnurseconsultants.com
Phone: 407-760-1662
Website: https://jrmnurseconsultants.com
You don’t have to navigate midlife changes alone—let’s take this journey together.